Yes. When comparing objects using the controllers, the columns that you can currently see are used for comparison. By clicking the “Columns” button on the ribbon bar you can configure which columns are displayed:
For example, say you would like to compare the versions of a program installed on multiple machines, while ignoring the differences in the installation path or install date. To do so, click the “Columns” button and deselect all columns except “Version”. Hit “Refresh” and the updated view will only show differences in version, but not in other columns.